@article{10.11648/j.sjc.20210906.14,
  author = {Charlemagne Ndoumbe Tamba and Sergi Herve Akone and Caroline Ngo Nyobe and Claudia Stevine Popwo Tameye and Jean Pierre Longue Ekon and Jules Lobe Songue and Jean Claude Ndom},
  title = {New Bioactive Flavonoid Derivative from the Leaves of Caloncoba echinata},
  journal = {Science Journal of Chemistry},
  volume = {9},
  number = {6},
  pages = {155-159},
  doi = {10.11648/j.sjc.20210906.14},
  url = {https://doi.org/10.11648/j.sjc.20210906.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20210906.14},
  abstract = {Background: Caloncoba echinata is used in traditional medicine as vomiting, against lice and mange as well as in the treatment of dermal infection, leprosy, pustular eruption (small-pox) [1, 4]. It has been reported that the non-edible vegetable oil from Caloncoba echinata seeds possess potent antibacterial activity on Escherichia coli and Staphylococcus aureus [5]. Objective: This work addressed the phytochemical investigation of the methanolic extract of leaves of Caloncoba echinate. Both extracts and all the isolates were screened for the antibacterial activities. Method: All the compounds were characterized by spectroscopic and mass spectrometric methods, and by comparison with literature data. The antibacterial activity of both extract and some isolated compounds against bacteria was determined using broth microdilution method in 96-well microtitre sterile plates as previously described [11]. Results: From the methanolic crude extract of the leaves of Caloncoba echinate, a new derivative flavonol named Kaempferol-4',7-dimethoxy-3-O-(6"-O-acetyl)-β-NULL-glucopyranoside (1) together with nine known compounds namely ermanin-3-O-β-D glucopyranoside (2), Kaempferol-4′,7-dimethoxy-3-O-(3",4",6"-O-triacetyl)-β-NULL glucopyranoside (3), friedelan-3-one (4), 29-hydroxyfriedelan-3-one (5), mixture of β-sitosterol and stigmasterol (6-7), mixture of β-sitosterol and stigmasterol glucoside (8-9), Lupeol (10) were isolated. Furthermore, compounds (2) and (5) were reported here for the first time from the Caloncoba genus. Crude extract exhibited a significant activity against the five bacteria with the MIC = 62.5µg/mL for Salmonella typhi, Escherishia coli, Shigella flexineri and the MIC = 32.25µg/mL for Salmonella typhimurium, S. enteritidis. For the isolated compounds, the best activities were recorded by compound (1) showing a moderate activity against Salmonella typhi (MIC = 32.25µg/mL; MBC/MIC = 8), Salmonella typhimurium (62.5µg/mL; MBC/MIC = 4), Salmonella enteritidis (62.25 µg/mL; MBC/MIC = 2). Conclusion: These results showed that the antimicrobial activities could be mainly attributed to the constituents of flavonol glycoside (1). In addition, the antibacterial bioactivities and determined constituents support the use of this specie by traditional healers to treat a certain number of bacterial diseases.},
 year = {2021}
}

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TY  - JOUR
T1  - New Bioactive Flavonoid Derivative from the Leaves of Caloncoba echinata
AU  - Charlemagne Ndoumbe Tamba
AU  - Sergi Herve Akone
AU  - Caroline Ngo Nyobe
AU  - Claudia Stevine Popwo Tameye
AU  - Jean Pierre Longue Ekon
AU  - Jules Lobe Songue
AU  - Jean Claude Ndom
Y1  - 2021/12/09
PY  - 2021
N1  - https://doi.org/10.11648/j.sjc.20210906.14
DO  - 10.11648/j.sjc.20210906.14
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 155
EP  - 159
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20210906.14
AB  - Background: Caloncoba echinata is used in traditional medicine as vomiting, against lice and mange as well as in the treatment of dermal infection, leprosy, pustular eruption (small-pox) [1, 4]. It has been reported that the non-edible vegetable oil from Caloncoba echinata seeds possess potent antibacterial activity on Escherichia coli and Staphylococcus aureus [5]. Objective: This work addressed the phytochemical investigation of the methanolic extract of leaves of Caloncoba echinate. Both extracts and all the isolates were screened for the antibacterial activities. Method: All the compounds were characterized by spectroscopic and mass spectrometric methods, and by comparison with literature data. The antibacterial activity of both extract and some isolated compounds against bacteria was determined using broth microdilution method in 96-well microtitre sterile plates as previously described [11]. Results: From the methanolic crude extract of the leaves of Caloncoba echinate, a new derivative flavonol named Kaempferol-4',7-dimethoxy-3-O-(6"-O-acetyl)-β-NULL-glucopyranoside (1) together with nine known compounds namely ermanin-3-O-β-D glucopyranoside (2), Kaempferol-4′,7-dimethoxy-3-O-(3",4",6"-O-triacetyl)-β-NULL glucopyranoside (3), friedelan-3-one (4), 29-hydroxyfriedelan-3-one (5), mixture of β-sitosterol and stigmasterol (6-7), mixture of β-sitosterol and stigmasterol glucoside (8-9), Lupeol (10) were isolated. Furthermore, compounds (2) and (5) were reported here for the first time from the Caloncoba genus. Crude extract exhibited a significant activity against the five bacteria with the MIC = 62.5µg/mL for Salmonella typhi, Escherishia coli, Shigella flexineri and the MIC = 32.25µg/mL for Salmonella typhimurium, S. enteritidis. For the isolated compounds, the best activities were recorded by compound (1) showing a moderate activity against Salmonella typhi (MIC = 32.25µg/mL; MBC/MIC = 8), Salmonella typhimurium (62.5µg/mL; MBC/MIC = 4), Salmonella enteritidis (62.25 µg/mL; MBC/MIC = 2). Conclusion: These results showed that the antimicrobial activities could be mainly attributed to the constituents of flavonol glycoside (1). In addition, the antibacterial bioactivities and determined constituents support the use of this specie by traditional healers to treat a certain number of bacterial diseases.
VL  - 9
IS  - 6
ER  - 

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